you have to install the Microsoft Access Database Engine 2010 Redistributable 32bit.
You can find it here: Download Microsoft Access Database Engine 2010 Redistributable from Official Microsoft Download Center

if you have installed already a office 64bit on your system you should install it as passive.
To do this you should open the windows command (CMD) as administrator and start the downloaded file with /passive.
Example: C:\PATHTOFOLDER\AccessDatabaseEngine.exe /passive

Before the MES4 is working, the file setupDB.exe in the MES4 folder should be started to create the database connection.